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pentobarbital will reduce the extent or impact of temsirolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will decrease the level or impact of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers have not been studied, coadministration not encour